Dermatomyositis with Rapidly Progressive Interstitial Lung Disease Treated with Rituximab: A Report of 3 Cases in Japan
نویسندگان
چکیده
We performed a retrospective chart review of three patients with hypomyopathic dermatomyositis and rapidly progressive interstitial lung disease. The patients were Japanese women of 71, 69, and 65 years of age. Two patients were anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive and 1 was anti-aminoacyl-tRNA synthetase (anti-ARS) antibody-positive. Their respiratory statuses deteriorated despite the administration of glucocorticoid, calcineurin inhibitors, and intravenous cyclophosphamide therapy. We subsequently administered rituximab. The anti-ARS antibody-positive patient survived, while 2 anti-MDA5 antibody-positive patients died.
منابع مشابه
Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review
We describe the case of a 48-year-old man with dermatomyositis (DM) who demonstrated rapidly progressive interstitial lung disease (RP-ILD) and refractory cutaneous involvement together with high levels of anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab). Even after combination immunosuppressive therapy including a corticosteroid, cyclosporine A, and intravenous cyclophos...
متن کاملCyclosporine treatment for interstitial pneumonitis associated with dermatomyositis/polymyositis.
Weread with interest the case report by Shinohara et al (1) and the editorial by Takizawa and Ito (2). Shinohara et al described a case of rapidly progressive interstitial lung disease associated with dermatomyositis (DM) who was successfully treated with cyclophosphamide pulse therapy. The case report and the editorial by Takizawa et al commenton the use of cyclosporine for this intractable in...
متن کاملAnti-Ro 52 positive dermatomyositis presenting as rapidly progressive interstitial lung disease.
Dermatomyositis is frequently accompanied by interstitial lung disease. This varies greatly in severity, from an asymptomatic imaging finding to a fatal rapidly progressive disease. We present a successfully treated case of rapidly progressive anti-Ro 52 positive dermatomyositis-related interstitial lung disease with accompanying images. A 48-year-old man presented with a 6-week history of dry ...
متن کاملAuthor's response to reviews Title: Myositis autoantibodies in Korean patients with inflammatory myositis: Anti-140-kDa polypeptide antibody is primarily associated with rapidly progressive interstitial lung disease independent of clinically amyopathic dermatomyositis. Authors:
Title: Myositis autoantibodies in Korean patients with inflammatory myositis: Anti-140-kDa polypeptide antibody is primarily associated with rapidly progressive interstitial lung disease independent of clinically amyopathic dermatomyositis.
متن کاملAmyopathic Dermatomyositis Associated with Histopathological Findings of Organizing Pneumonia and Pulmonary Vasculitis
BACKGROUND Clinically, amyopathic dermatomyositis is a clinically distinct subgroup of dermatomyositis characterised by unique dermatological manifestations without muscle involvement. Clinically, amyopathic dermatomyositis is frequently associated with interstitial lung disease, which usually has a rapidly progressive, fatal clinical course. Although clinically, amyopathic dermatomyositis-rela...
متن کامل